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Protein networks markedly improve prediction of subcellular localization in multiple eukaryotic species.

Lee, Kiyoung Chuang, Han-Yu Beyer, Andreas Sung, Min-Kyung Huh, Won-Ki Lee, Bonghee Ideker, Trey

Published in Nucleic acids research

The function of a protein is intimately tied to its subcellular localization. Although localizations have been measured for many yeast proteins through systematic GFP fusions, similar studies in other branches of life are still forthcoming. In the interim, various machine-learning methods have been proposed to predict localization using physical ch...

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