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Integrating physical and genetic maps: from genomes to interaction networks.

Beyer, A Bandyopadhyay, S Trey Ideker

Physical and genetic mapping data have become as important to network biology as they once were to the Human Genome Project. Integrating physical and genetic networks currently faces several challenges: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway model...

Integrative approaches for finding modular structure in biological networks.

Mitra, Koyel Carvunis, Anne-Ruxandra Ramesh, Sanath Kumar Ideker, Trey

Published in Nature reviews. Genetics

A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with diverse molecu...

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Integrating physical and genetic maps: from genomes to interaction networks.

Integrative approaches for finding modular structure in biological networks.