Lee, KiYoung Byun, Kyunghee Hong, Wonpyo Chuang, Han-Yu Pack, Chan-Gi Bayarsaikhan, Enkhjargal Paek, Sun Ha Kim, Hyosil Shin, Hye Young Ideker, Trey
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Published in
Genome research
Several studies have sought systematically to identify protein subcellular locations, but an even larger task is to map which of these proteins conditionally relocates in disease (the mislocalizome). Here, we report an integrative computational framework for mapping conditional location and mislocation of proteins on a proteome-wide scale, called a...
Henikoff, Steven Henikoff, Jorja G Sakai, Akiko Loeb, Gabriel B Ahmad, Kami
Published in
Genome research
We applied genome-wide profiling to successive salt-extracted fractions of micrococcal nuclease-treated Drosophila chromatin. Chromatin fractions extracted with 80 mM or 150 mM NaCl after digestion contain predominantly mononucleosomes and represent classical "active" chromatin. Profiles of these low-salt soluble fractions display phased nucleosome...
