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Inferring gene ontologies from pairwise similarity data. PDF available through Get Fulltext Research

Kramer, Michael Dutkowski, Janusz Yu, Michael Bafna, Vineet Ideker, Trey

Published in Bioinformatics (Oxford, England)

While the manually curated Gene Ontology (GO) is widely used, inferring a GO directly from -omics data is a compelling new problem. Recognizing that ontologies are a directed acyclic graph (DAG) of terms and hierarchical relations, algorithms are needed that: analyze a full matrix of gene-gene pairwise similarities from -omics data; infer true hier...

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